Citation: Jie-Xiong Wang, Jing-Jing Wu, Heng Chen, Shao-Wu Zhang, Fan-Hong Wu. Synthesis of difluoroalkyl-γ-butyrolactones from iododifluoromethyl ketones and 4-pentenoic acids[J]. Chinese Chemical Letters, ;2015, 26(11): 1381-1384. doi: 10.1016/j.cclet.2015.07.007 shu

Synthesis of difluoroalkyl-γ-butyrolactones from iododifluoromethyl ketones and 4-pentenoic acids

1.
a School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201814, China;
2.
b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201814, China

Corresponding author: Jing-Jing Wu, Fan-Hong Wu,
Received Date: 4 May 2015
Available Online: 24 June 2015

A convenient and efficient approach for difluoroalkyl-containing γ-butyrolactones via the radical addition reaction of iododifluoromethyl ketones with 4-pentenoic acids initiated by AIBN in CH₃CN at 60 ℃ was reported. Various difluoroalkyl-containing δ-valerolactones were also synthesized under this reaction conditions.
- γ-Butyrolactones
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