Citation: Yan-Zuo Chen, Yu-Kun Huang, Yuan Chen, Ya-Jing Ye, Kai-Yan Lou, Feng Gao. Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier[J]. Chinese Chemical Letters, ;2015, 26(7): 909-913. doi: 10.1016/j.cclet.2015.05.044 shu

Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier

Yan-Zuo Chen ^a,b,c ,
Yu-Kun Huang ^a,b ,
Yuan Chen ^b,d ,
Ya-Jing Ye ^a,b ,
Kai-Yan Lou ^b ,
Feng Gao ^a,b,c,,

1.
a Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China;
2.
b Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;
3.
c Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China;
4.
d Shanghai Institute of Health Sciences, Shanghai 201318, China

Corresponding author: Feng Gao,
Received Date: 31 March 2015
Available Online: 7 May 2015
Fund Project: This work was financially supported by Postdoctoral Science Foundation of China (No. 2014M550222) (No. 2014M550222) Shanghai Postdoctoral Sustentation Fund (No. 14R21410500). The authors also acknowledge the support from School of Pharmacy, Fudan University & the Open Project Program of Key Lab of Smart Drug Delivery (Fudan University) (No. 14R21410500) Ministry of Education (No. SDD2014-2) (No. SDD2014-2) State Key Laboratory of Molecular Engineering of Polymers (Fudan University, No. K2015-15) (Fudan University, No. K2015-15)

This research was aim to develop novel cyclodextrin/chitosan (CD/CS) nanocarriers for insoluble drug delivery through themild ionic gelation method previously developed by our lab. A series of different bcyclodextrin (β-CD) derivatives were incorporated into CS nanoparticles including hydroxypropyl-bcyclodextrin (HP-β-CD), sulphobutylether-β-cyclodextrin (SB-β-CD), and 2,6-di-O-methy-β-cyclodextrin (DM-β-CD). Various process parameters for nanoparticle preparation and their effects on physicochemical properties of CD/CS nanoparticles were investigated, such as the type of CD derivatives, CD and CS concentrations, the mass ratio of CS to TPP (CS/TPP), and pH values. In the optimal condition, CD/CS nanoparticles were obtained in the size range of 215-276 nm and with the zeta potential from 30.22 mV to 35.79 mV. Moreover, the stability study showed that the incorporation of CD rendered the CD/CS nanocarriers more stable than CS nanoparticles in PBS buffer at pH 6.8. For their easy preparation and adjustable parameters in nanoparticle formation as well as the diversified hydrophobic core of CD derivatives, the novel CD/CS nanoparticles developed herein might represent an interesting and versatile drug delivery platform for a variety of poorly water-soluble drugs with different physicochemical properties.
- Chitosan,
- Cyclodextrin derivatives,
- Ionic gelation method,
- Drug delivery system
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