Citation: Wen-Jing Hu, Ming-Liang Ma, Yahu A. Liu, Jiu-Sheng Li, Biao Jiang, Ke Wen. Synthesis and structures of malonate derivative-calix[4]arene conjugates[J]. Chinese Chemical Letters, ;2015, 26(7): 914-917. doi: 10.1016/j.cclet.2015.05.017 shu

Synthesis and structures of malonate derivative-calix[4]arene conjugates

Wen-Jing Hu ^a ,
Ming-Liang Ma ^b,, ,
Yahu A. Liu ^c ,
Jiu-Sheng Li ^a ,
Biao Jiang ^a ,
Ke Wen ^a,b,d,,

1.
a Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China;
2.
b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China;
c Medicinal Chemistry, ChemBridge Research Laboratories Inc.
c Medicinal Chemistry, ChemBridge Research Laboratories Inc., San Diego, CA 92127, USA;
4.
d School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China

Corresponding author: Ming-Liang Ma, Ke Wen,
Received Date: 31 March 2015
Available Online: 17 April 2015
Fund Project: Financial support from the National Natural Science Foundation of China (No. 21371177) is acknowledged. (No. 21371177)

A series of malonate derivatives-calix[4]arene conjugates were synthesized through Knoevenagel condensation reaction between formyl-tetrapropoxycalix[4]arene and malonate derivatives. The structures of the resulting malonate derivative functionalized calix[4]arenes were characterized by NMR spectroscopy, mass spectrometry and even single crystal X-ray diffraction analysis.
- Calix[4]arene,
- Malonate derivatives,
- Knoevenagel condensation reaction
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