Citation: Yang-Qiu Peng, Lai-Chun Luo, Jiao Gong, Jian Huang, Qi Sun. New synthetic approach for the preparation of 2-aryl-thiazolo[4,5-b]pyridines via Liebeskind-Srogl reaction[J]. Chinese Chemical Letters, ;2015, 26(8): 1016-1018. doi: 10.1016/j.cclet.2015.05.012 shu

New synthetic approach for the preparation of 2-aryl-thiazolo[4,5-b]pyridines via Liebeskind-Srogl reaction

1.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Corresponding author: Qi Sun,
Received Date: 18 March 2015
Available Online: 17 April 2015
Fund Project: This research was supported by the National Natural Science Foundation of China (No. 21272009). (No. 21272009)

The potentially bioactive 2-aryl-thiazolo[4,5-b]pyridines were synthesized via palladium-catalyzed desulfitative cross-coupling reaction between multisubstituted thiazolo[4,5-b]pyridine thioethers and boronic acids. Yields of 48%-94% were obtained with copper(I) thiophene-2-carboxylate in the system.
- Liebeskind-Srogl reaction,
- Desulfitative cross-coupling,
- Palladium,
- N-fused heterocycles
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沈阳化工大学材料科学与工程学院沈阳 110142