Citation: Guang-Zong Tian, Xiao-Li Wang, Jing Hu, Xue-Bin Wang, Xiao-Qiang Guo, Jian Yin. Recent progress of sugar amino acids: Synthetic strategies and applications as glycomimetics and peptidomimetics[J]. Chinese Chemical Letters, ;2015, 26(8): 922-930. doi: 10.1016/j.cclet.2015.04.026 shu

Recent progress of sugar amino acids: Synthetic strategies and applications as glycomimetics and peptidomimetics

Guang-Zong Tian ^a,c ,
Xiao-Li Wang ^a,c ,
Jing Hu ^b ,
Xue-Bin Wang ^a,c ,
Xiao-Qiang Guo ^a,c ,
Jian Yin ^a,c,,

1.
a Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China;
2.
b Wuxi Medical School, Jiangnan University, Wuxi 214122, China;
3.
c Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, China

Corresponding author: Jian Yin,
Received Date: 16 December 2014
Available Online: 27 March 2015
Fund Project: This studywas supported by the National Science Foundation for Young Scientists of China (No. 21302068) (No. 21302068) the Natural Science Foundation of Jiangsu Province, China (No. BK20130127) (No. BK20130127) Jiangsu Province "Six Summit Talent" Foundation (No. 2012-SWYY-009) (No. 2012-SWYY-009) the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20120093120002) (No. 20120093120002)the Fundamental Research Funds for theCentral Universities (Nos. JUSRP51319B, JUSRP51411B). (Nos. JUSRP51319B, JUSRP51411B)

In order to meet the increasing demands for the development of large varieties of new molecules for discovering new drugs and materials, organic chemists are developing many novel multifunctional building blocks, which are assembled rationally to create ‘nature-like’ and yet unnatural organic molecules with well-defined structures and useful properties. Sugar amino acids (SAAs), the carbohydrate derivatives bearing both amino and carboxylic acid functional groups, are important ones of thesemultifunctional building blocks, which can be used to create novelmaterials with potential applications as glycomimetics and peptidomimetics. This review will focus on recent synthetic strategies of SAAs and their applications in creating large number of structurally diverse glycomimetics and peptidomimetics.
- Sugar amino acids,
- Synthetic strategy,
- Glycomimetics,
- Peptidomimetics
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