Citation: Xiao-Zhen Cui, Zhi-Guo Zhou, Yan Yang, Jie Wei, Jun Wang, Ming-Wei Wang, Hong Yang, Ying-Jian Zhang, Shi-Ping Yang. PEGylated WS₂ nanosheets for X-ray computed tomography imaging and photothermal therapy[J]. Chinese Chemical Letters, ;2015, 26(6): 749-754. doi: 10.1016/j.cclet.2015.03.034 shu

PEGylated WS₂ nanosheets for X-ray computed tomography imaging and photothermal therapy

Xiao-Zhen Cui ^a ,
Zhi-Guo Zhou ^a,, ,
Yan Yang ^a ,
Jie Wei ^a ,
Jun Wang ^a ,
Ming-Wei Wang ^b,c,d,, ,
Hong Yang ^a ,
Ying-Jian Zhang ^b,c,d ,
Shi-Ping Yang ^a

1.
a The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China;
2.
b Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China;
3.
c Center for Biomedical Imaging, Fudan Univerisity, Shanghai 200032, China;
4.
d Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Corresponding author: Zhi-Guo Zhou, Ming-Wei Wang,
Received Date: 31 December 2014
Available Online: 28 February 2015
Fund Project: Shanghai Pujiang Program (No. 13PJ1406600) (No. IRT1269)

WS₂ nanosheets were prepared by the solvent-thermal method in the presence of n-butyl lithium, then the exfoliation under the condition of ultrasound. The formed WS₂ nanosheets were conjugated with thiol-modified polyethylene glycol (PEG-SH) to improve the biocompatibility. The nanosheets (WS₂-PEG) were able to inhibit the growth of a model HeLa cancer cell line in vitro due to the high photothermal conversion efficiency of 35% irradiated by an 808 nm laser (1 W/cm²). As a proof of concept, WS₂-PEG nanosheets with the better X-ray attenuation property than the clinical computed tomography (CT) contrast agent (Iohexol) could be performed for CT imaging of the lymph vessel.
- WS₂ nanosheets,
- CT imaging,
- Photothermal therapy,
- In vivo
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

PEGylated WS2 nanosheets for X-ray computed tomography imaging and photothermal therapy

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通讯作者: 陈斌, bchen63@163.com

PEGylated WS₂ nanosheets for X-ray computed tomography imaging and photothermal therapy