Citation: Shi Tang, Zhi-yong Wang, Bin Liu, Chun-E. Dong. C₂-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates[J]. Chinese Chemical Letters, ;2015, 26(6): 744-748. doi: 10.1016/j.cclet.2015.03.033 shu

C₂-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates

1.
State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China

Corresponding author: Chun-E. Dong,
Received Date: 17 December 2014
Available Online: 5 March 2015
Fund Project: We are grateful to the Fundamental Research Funds for the Central Universities (No. 2042014kf0248) for support of this research. (No. 2042014kf0248)

The asymmetric α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates has been achieved by C₂-symmetric BINOL-squaramide bearing multiple hydrogen bond donors to provide the desired products in excellent yields and enantioselectivities (up to 99% yield and 98% ee).
- Asymmetric amination,
- 1,3-Dicarbonyl compound,
- Dialkyl azodicarboxylates
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通讯作者: 陈斌, bchen63@163.com

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C2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates

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通讯作者: 陈斌, bchen63@163.com

C₂-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates