Citation: Xin-Yu Bian, Serge Maurice Mbadinga, Shi-Zhong Yang, Ru-Qiang Ye, Ji-Dong Gu, Bo-Zhong Mua. Synthesis of 2-[²H]-2-(1-methylalkyl)succinic acids[J]. Chinese Chemical Letters, ;2015, 26(5): 619-622. doi: 10.1016/j.cclet.2015.01.010 shu

Synthesis of 2-[²H]-2-(1-methylalkyl)succinic acids

1.
a State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry, East China University of Science and Technology, Shanghai 200237, China;
2.
b School of Biological Sciences, The University of Hong Kong, Hong Kong, China

Received Date: 17 September 2014
Available Online: 25 December 2014
Fund Project: This work was supported by the National Natural Science Foundation of China (No. 41373070, 51174092) (No. 41373070, 51174092)the National Natural Science Foundation of China/Research Grants Council Joint Research Fund (No. 41161160560). (No. 41161160560)

We describe a specific procedure for the synthesis of deuterium-labelled 2-(1-methylalkyl)succinate established via alkylation of diethyl malonate, Krapcho decarboxylation reaction with D₂O and hydrolysis reaction. Two novel compounds, 2-[²H]-2-ethylsuccinic acid and 2-[²H]-2-(1-methylheptyl) succinic acid were prepared via this synthetic route and characterized by mass spectrometry and ¹H NMR. The results showed that the 2-(1-methylalkyl)succinic acids were deuterated at the β-position, which is considered as an important reaction centre in the anaerobic degradation of n-alkanes.
- Deuterium-labelled biomarkers,
- 2-(1-Methylalkyl)succinates,
- Fumarate addition,
- Anaerobic degradation of alkanes
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1.
沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis of 2-[2H]-2-(1-methylalkyl)succinic acids

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通讯作者: 陈斌, bchen63@163.com

Synthesis of 2-[²H]-2-(1-methylalkyl)succinic acids