Citation: Ru-Wei Shen, Jian-Jun Yang, Li-Xiong Zhang. Facile synthesis of phthalan derivatives via a Pd-catalyzed tandem hydroalkynylation, isomerization, Diels-Alder cycloaddition and aromatization reaction[J]. Chinese Chemical Letters, ;2015, 26(1): 73-76. doi: 10.1016/j.cclet.2014.10.018 shu

Facile synthesis of phthalan derivatives via a Pd-catalyzed tandem hydroalkynylation, isomerization, Diels-Alder cycloaddition and aromatization reaction

1.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China

Corresponding author: Ru-Wei Shen, Li-Xiong Zhang,
Received Date: 11 August 2014
Available Online: 10 October 2014
Fund Project: The financial support from the National Natural Science Foundation of China (No. 21302095) (No. 21302095) Research Fund for the Doctoral Program of Higher Education of China (No. 20133221120003) (No. 20133221120003) Jiangsu Provincial NSFC (No. BK20130924) (No. BK20130924)Foundation of Jiangsu Educational Committee of China (No. 13KJB150019) is fully acknowledged. (No. 13KJB150019)

A novel Pd-catalyzed tandem reaction involving hydroalkynylation, isomerization, Diels-Alder cycloaddition and aromatization reaction to produce phthalan derivatives in moderate yields is reported. The reaction is atom economical and occurs in a highly ordered fashion. The reaction mechanism is discussed.
- Tandem reaction,
- Palladium catalysis,
- Alkyne,
- Phthalan,
- Diels-Alder cycloaddition
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沈阳化工大学材料科学与工程学院沈阳 110142