Citation: Qi Sun, Jian Sun, Shan-Shan Gong, Cheng-Jun Wang, Xing-Cong Wang. Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates from nucleoside phosphoropiperidates via the activation of P(V)-N bond[J]. Chinese Chemical Letters, ;2015, 26(1): 89-92. doi: 10.1016/j.cclet.2014.09.015 shu

Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates from nucleoside phosphoropiperidates via the activation of P(V)-N bond

1.
Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China

Corresponding author: Qi Sun,
Received Date: 12 June 2014
Available Online: 11 September 2014
Fund Project: Scientific Research Foundation of Chinese Ministry of Human Resources and Social Security for Returned Chinese Scholars (2011) (No. 212092)Startup Funds for PhDs (2010) from JXSTNU for financial support. (2011)

A novel and efficient method for the preparation of nucleoside 50-tetraphosphates has been developed by coupling nucleoside 5'-phosphoropiperidates with triphosphate reagent in the presence of 4, 5-dicyanoimidazole (DCI) activator. Further coupling of the nucleoside 5'-tetraphosphates with nucleoside 50-phosphoropiperidates via the P(V)-N activation strategy provided a reliable synthetic method for both symmetrical and asymmetrical dinucleoside pentaphosphates.
- 4,5-Dicyanoimidazole,
- Phosphoropiperidate,
- Nucleoside tetraphosphate,
- Dinucleoside pentaphosphate,
- P(V)-N activation
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沈阳化工大学材料科学与工程学院沈阳 110142