Citation: Cai-Xia Yin, Li-Jun Qu, Fang-Jun Huo. A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging[J]. Chinese Chemical Letters, ;2014, 25(9): 1230-1234. doi: 10.1016/j.cclet.2014.06.017 shu

A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging

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a Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China;
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b Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China

Corresponding author: Fang-Jun Huo,
Received Date: 31 March 2014
Available Online: 16 June 2014
Fund Project: The work was supported by the National Natural Science Foundation of China (No. 21102086) (No. 21102086) the Taiyuan Technology Star Special (No. 12024703) (No. 2012-007) the Program for the Top Young and Middle-aged Innovative Talents of Higher Learning Institutions of Shanxi (TYMIT, No. 2013802) (No. 12024703)CAS Key Laboratory of Analytical Chemistry for Living Biosystems Open Foundation (No. ACL201304). (TYMIT, No. 2013802)

A pyridoxal-based chemosensor was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were investigated in a methanol: HEPES solution. The compound displayed selectivity for Cu²⁺, as evidenced by a colorless to yellow color change, which was characterized using UV-vis spectroscopy. The fluorescence of the compound can be quenched only by Cu²⁺, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging.
- Pyridoxal-based,
- Copper ion,
- Chemosensor,
- Bioimaging
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