Citation: Wei-Xia Song, Yong-Chun Yang, Jian-Gong Shi. Two new β-hydroxy amino acid-coupled secoiridoids from the fl ower buds of Lonicera japonica：Isolation, structure elucidation, semisynthesis, and biological activities[J]. Chinese Chemical Letters, ;2014, 25(9): 1215-1219. doi: 10.1016/j.cclet.2014.05.037 shu

Two new β-hydroxy amino acid-coupled secoiridoids from the fl ower buds of Lonicera japonica：Isolation, structure elucidation, semisynthesis, and biological activities

1.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Corresponding author: Jian-Gong Shi,
Received Date: 17 March 2014
Available Online: 29 April 2014
Fund Project:

Two new β-hydroxy amino acid-coupled secoiridoids, named serinosecologanin (1) and threoninosecologanin (2), were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their uncommon structures including absolute configurations were determined by spectroscopic data analysis, and confirmed by semisynthesis from the co-occurring secologanin (3) and secologanic acid (4). Compounds 1 and 2 exhibited resistant activity against β-glucosidase from almonds and hesperidinase from Aspergillus niger, they also showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor with inhibition rates of (34.9±3.1)% and (53.6±2.6)%, respectively.
- Lonicera japonica,
- Caprifoliaceae,
- β-Hydroxy amino acid-coupled secoirridoid,
- Isolation,
- Structure elucidation,
- Semisynthesis,
- Biological activity
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沈阳化工大学材料科学与工程学院沈阳 110142