Citation: Dao-Cai Wang, Yong-Mei Xie, Chen Fan, Shun Yao, Hang Song. Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity[J]. Chinese Chemical Letters, ;2014, 25(7): 1011-1013. doi: 10.1016/j.cclet.2014.04.026 shu

Effi cient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity

Dao-Cai Wang ^a ,
Yong-Mei Xie ^b ,
Chen Fan ^b ,
Shun Yao ^a ,
Hang Song ^a,,

1.
a Department of Pharmaceutical and Biological Engineering, College of Chemical Engineering, Sichuan University, Chengdu 610065, China;
2.
b State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

Corresponding author: Hang Song,
Received Date: 11 March 2014
Available Online: 16 April 2014
Fund Project:

A series of novel 2-amino-4H-pyran derivatives have been synthesized via a three-component reaction of a, β-unsaturated ketone derivatives, malononitrile, aldehydes in excellent yields, using DBU as a catalyst and ethanol as a cheap, safe, and environmentally benign solvent under mild conditions. Their antitumor activity was evaluated in three human tumor cell lines, including human colon cancer (HCT116), human cervical cancer (Hela), and non-small cell lung cancer (H1975).
- Synthesis,
- 2-Amino-4H-pyran derivatives,
- Multicomponent,
- Anticancer
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沈阳化工大学材料科学与工程学院沈阳 110142