Citation: Wei Liu, Li-Ya Han, Rui-Li Liu, Li-Ge Xu, Yan-Lan Bi. Copper-catalyzed N-arylation of 2-arylindoles with aryl halides[J]. Chinese Chemical Letters, ;2014, 25(9): 1240-1243. doi: 10.1016/j.cclet.2014.04.021 shu

Copper-catalyzed N-arylation of 2-arylindoles with aryl halides

1.
College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China

Corresponding author: Wei Liu,
Received Date: 28 March 2014
Available Online: 14 April 2014
Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21102036) (No. 21102036)Plan for Scientific Innovation Talent of Henan University of Technology (No. 11CXRC02) (No. 11CXRC02)startup fund from HAUT (No. 2010BS042). (No. 2010BS042)

10 mol% CuI combined with the DMEDA ligand can efficiently catalyze the N-arylation of 2-arylindoles with aryl iodides and aryl bromides in good to excellent yields. The aryl halides bearing electron-rich or electron-deficient functional groups can be well tolerated under this mild reaction conditions.
- 2-Arylindoles,
- Aryl halides,
- N-Arylation,
- Copper
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沈阳化工大学材料科学与工程学院沈阳 110142