Citation: Qing-Han Li, Yong Ding, Xue-Jun Yang. Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents[J]. Chinese Chemical Letters, ;2014, 25(9): 1296-1300. doi: 10.1016/j.cclet.2014.04.019 shu

Nickel-catalyzed cross-coupling reaction of alkynyl bromides with Grignard reagents

1.
College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China

Corresponding author: Qing-Han Li,
Received Date: 31 January 2014
Available Online: 4 April 2014
Fund Project: This work was financially supported by the Fundamental Research Funds for the Central Universities, Southwest University for Nationalities (No. 12NZYTH03) (No. 12NZYTH03) and the Project of Postgraduate Degree Construction, Southwest University for Nationalities (No. 2013XWD-S0703) (No. 381010)

We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of (bromoethynyl)benzene with Grignard reagents. The reaction of (bromoethynyl)benzene (1 mmol) with Grignard reagent (1.3 mmol) mediated by NiCl₂ (4 mol%) and (p-CH₃Ph)3P (8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.
- 1,2-Disubstituted acetylene,
- Nickel,
- (Bromoethynyl)benzene,
- Grignard reagent,
- Cross-coupling
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沈阳化工大学材料科学与工程学院沈阳 110142