Citation: Mehul B. Kanani, Manish P. Patel. Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation[J]. Chinese Chemical Letters, ;2014, 25(7): 1073-1076. doi: 10.1016/j.cclet.2014.04.002 shu

Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation

Mehul B. Kanani ,
Manish P. Patel ^,

1.
Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, India

Corresponding author: Manish P. Patel,
Received Date: 3 December 2013
Available Online: 25 March 2014

A new series of 2-thiophenoxyquinolines based trifluoromethyl substituted N-aryl quinolone derivatives 8a-f and 9a-f have been synthesized via a one-pot multicomponent reaction. In vitro antimicrobial activity of the synthesized compounds was investigated against a representative panel of pathogenic strains. Compounds 8c, 9c and 9e exhibited comparable antimicrobial activity to first line drugs.
- 2-Thiophenoxyquinoline,
- Trifluoromethyl,
- N-Aryl quinolone,
- Antimicrobial activity
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