Citation: Aida Chaker, Fathi Zribi, Françoise Nepveu, Fakher Chabchoub. Microwave irradiation：Novel and facile methods for the synthesis of new pyrimidinones[J]. Chinese Chemical Letters, ;2014, 25(8): 1207-1210. doi: 10.1016/j.cclet.2014.03.048 shu

Microwave irradiation：Novel and facile methods for the synthesis of new pyrimidinones

1.
a Department of Chemistry, University of Sfax, Road Soukra km 4-3000 Sfax, Tunisia;
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b UPS, UMR 152 PHARMA-DEV, University of Toulouse III, 118 road of Narbonne, F-31062 Cedex 9 Toulouse, France;
3.
c IRD, UMR 152, F-31062 Cedex 9 Toulouse, France

Corresponding author: Fakher Chabchoub,
Received Date: 7 October 2013
Available Online: 10 March 2014

We describe here a rapid process for the preparation of new 9-chloromethyl-12-aryl-10,12-dihydrobenzo[5,6]chromeno[2,3-d]pyrimidin-11-ones 5a-d and 10-chloromethyl-7-aryl-7,9-dihydrobenzo[7,8]chromeno[2,3-d]pyrimidin-8-ones 6a-d by two different methods utilizing microwave irradiation. This methodology provides better yields (72%-80%) and high purity of the title compounds.
- Microwave-irradiation,
- Aminonitriles naphtopyraniques,
- Chloroacetylchloride,
- Pyrimidinones
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