Citation: Pravinkumar N. Sable, Swastika Ganguly, Pravin D. Chaudhari. An effi cient one-pot three-component synthesis and antimicrobial evaluation of tetra substituted thiophene derivatives[J]. Chinese Chemical Letters, ;2014, 25(7): 1099-1103. doi: 10.1016/j.cclet.2014.03.044 shu

An effi cient one-pot three-component synthesis and antimicrobial evaluation of tetra substituted thiophene derivatives

1.
a Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 835215, India;
2.
b Department of Pharmaceutical Chemistry, Progressive Education Society's Modern College of Pharmacy Nigdi, Pune 411044, India

Corresponding author: Pravinkumar N. Sable,
Received Date: 11 September 2013
Available Online: 4 March 2014

A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction of acetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyl derivatives 3a-3c in the presence of potassium carbonate afforded the target compounds, namely ethyl 2-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-2-oxoacetate derivatives 4a-4e, ethyl 3-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-3-oxopropanoate derivatives 4f-4i, di((4-acetyl-3-methyl-5-phenylamino)thiophen-2-yl)ketone derivatives 4j-4n in reasonable overall yields. The synthesized compounds were screened for antimicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported.
- Thiophene,
- Multicomponent reaction,
- One pot reaction,
- Antimicrobial agents
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沈阳化工大学材料科学与工程学院沈阳 110142