Citation: Ri-Dao Chen, Zheng Yan, Jian-Hua Zou, Nan Wang, Jun-Gui Dai. Rubratoxin C, a new nonadride derivative from an endophytic fungus Penicillium sp. F-14[J]. Chinese Chemical Letters, ;2014, 25(9): 1308-1310. doi: 10.1016/j.cclet.2014.03.040 shu

Rubratoxin C, a new nonadride derivative from an endophytic fungus Penicillium sp. F-14

1.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China

Corresponding author: Jun-Gui Dai,
Received Date: 26 January 2014
Available Online: 18 March 2014
Fund Project: Thisworkwasfinanciallysupportedbythe Science&Technology Project of Guangdong Province (No. 2011A080403020) (No. 2011A080403020) the Fundamental Research Funds for the Central Universities (No. 2012N06) (No. 2012N06)

One new nonadride derivative rubratoxin C (1) together with a known compound rubratoxin B (2) were isolated from an endophytic fungus Penicillium sp. F-14. Their structures were elucidated by various spectroscopicmethods. Bioassays showed that 2 had moderate cytotoxic effect against HCT-8, BEL-7402, Ketr3, A2780, MCF-7 and BGC-823 human cancer cell lines, and 1 exhibited weak activity.
- Nonadride derivative,
- Endophytic fungus,
- Natural products,
- Cytotoxic activity
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沈阳化工大学材料科学与工程学院沈阳 110142