Citation: Yu-Bo Jiang, Wen-Sheng Zhang, Hui-Ling Cheng, Yu-Qi Liu, Rui Yang. One-pot synthesis of N-aryl propargylamine from aromatic boronic acid, aqueous ammonia, and propargyl bromide under microwave-assisted conditions[J]. Chinese Chemical Letters, ;2014, 25(05): 779-782. doi: 10.1016/j.cclet.2014.03.011 shu

One-pot synthesis of N-aryl propargylamine from aromatic boronic acid, aqueous ammonia, and propargyl bromide under microwave-assisted conditions

1.
a Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China;
2.
b School of Science and Technology, Jiaozuo Teachers' College, Jiaozuo 454001, China

Corresponding author: Yu-Bo Jiang,
Received Date: 15 November 2013
Available Online: 20 February 2014
Fund Project: The authors would like to thank the National Natural Science Foundation of China (No. 21262020) (No. 21262020) the Natural Science Foundation of Yunnan Education Department (No. 09Y0081) (No. KKSY201207140) and the Analysis and Measurement Foundation of Kunming University of Science and Technology (No. 20130560) for their financial supports. (No. 09Y0081)

A facile, one-pot synthesis of N-aryl propargylamine from aromatic boronic acid, aqueous ammonia, and propargyl bromide has been achieved under microwave-assisted conditions. The reactions can be smoothly completed within a total 10 min through a two-step procedure, including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.
- One-pot,
- Microwave,
- N-Aryl propargylamine,
- Aromatic boronic acid,
- Aqueous ammonia,
- Propargyl bromide
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