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Citation:
Shi-Ji Xiao, Fang Chen, Li-Sheng Ding, Yan Zhou. Two new eupodienone lignans from Gymnotheca chinensis[J]. Chinese Chemical Letters,
;2014, 25(3): 463-464.
doi:
10.1016/j.cclet.2013.11.053
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Two new eupodienone lignans, named gymnothelignan T (1) and gymnothelignan U (2) were isolated from the whole plants of endemicmedicinal plant of Gymnotheca chinensis (Saururaceae). The structures of the new compounds were elucidated by means of HRMS, 1D and 2D NMR. Compound 1 was tested for cytotoxic activity in HCT15, HCT116, A549, MCF-7 and HepG2 cells and exhibited no appreciable activity against these tested cell lines with IC50 values above 50 μmol/L.
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Keywords:
- Gymnotheca chinensis,
- Saururaceae,
- Eupodienone,
- Lignan
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[1]
[1] Y.Q. Cheng, Flora of China, Science Press, Beijing, 1982, p. 9.
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[2]
[2] D.H. He, L.S. Ding, H.X. Xu, et al., Gymnothelignans A-O: conformation and absolute configuration analyses of lignans bearing tetrahydrofuran from Gymnotheca chinensis, J. Org. Chem. 77 (2012) 8435-8443.
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[3]
[3] B.F. Bowden, R.W. Read, W.C. Taylor, Constituents of Eupomatia species. VI. The structures of eupodienone-1,-2,-3, Aust. J. Chem. 33 (1980) 1823-1831.
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[4]
[4] B.F. Bowden, R.W. Read, W.C. Taylor, Constituents of Eupomatia species. Ⅶ. Dienone-phenol and dienol-benzene rearrangements in the eupodienone-1 series, Aust. J. Chem. 34 (1981) 799-817.
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[5]
[5] R.W. Read, W.C. Taylor, Constituents of Eupomatia species. Ⅷ. The structures of eupodienone-4,-5,-6,-7, Aust. J. Chem. 34 (1981) 1125-1134.
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[6]
[6] A.R. Carroll, W.C. Taylor, Constituents of Eupomatia species. XⅢ. The structures of new lignans from the tubexs and aerial parts of Eupomatia bennettii, Aust. J. Chem. 44 (1991) 1627-1633.
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[7]
[7] A.R. Carroll, W.C. Taylor, Constituents of Eupomatia species. XIV. The structures of eupomatilone-1,-2,-3,-4,-5,-6 and-7 isolated from Eupomatia bennettii, Aust. J. Chem. 44 (1991) 1705-1714.
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