Citation: Kamalakar P. Nandre, Jagdish K. Salunke, Jitendra P. Nandre, Vijay S. Patil, Amul U. Borse, Sidhanath V. Bhosale. Glycerol mediated synthesis of 5-substituted 1H-tetrazole under catalyst free conditions[J]. Chinese Chemical Letters, ;2012, 23(2): 161-164. doi: 10.1016/j.cclet.2011.11.019 shu

Glycerol mediated synthesis of 5-substituted 1H-tetrazole under catalyst free conditions

a Department of Organic Chemistry, North Maharashtra University, Jalgaon 425001, India;
b School of Chemical Sciences, North Maharashtra University, Jalgaon 425001, India

Received Date: 24 August 2011

Fund Project: We are grateful for the financial support from Department of Atomic Energy-Board of Research in Nuclear Sciences (DAE-BRNS) (No. 2009/37/39/BRNS/2268), Mumbai, India and North Maharashtra University, Jalgaon for providing necessary facilities.

We have developed simple, cost effective and environmentally benign protocol for the synthesis of 5-substituted 1H-tetrazoles via [2,3] cycloaddition reaction from organic nitriles and sodium azide in glycerol under catalyst free condition. The corresponding 5-substituted 1H-tetrazoles were obtained with good to excellent yields (68-95%).
- 5-Substituted 1H-tetrazole,
- [2,3] Cycloaddition,
- Nitriles,
- Glycerol,
- Catalyst free
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