引用本文:
Yan Liu, Wu Zhong, Song Li. Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors[J]. Chinese Chemical Letters,
2012, 23(2): 133-136.
doi:
10.1016/j.cclet.2011.11.017
Citation: Yan Liu, Wu Zhong, Song Li. Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors[J]. Chinese Chemical Letters, 2012, 23(2): 133-136. doi: 10.1016/j.cclet.2011.11.017
Citation: Yan Liu, Wu Zhong, Song Li. Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors[J]. Chinese Chemical Letters, 2012, 23(2): 133-136. doi: 10.1016/j.cclet.2011.11.017
Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors
摘要:
A short and efficient synthesis of (Z)-2-substituted-5-(4-((2-substitued-5-oxoimidazolidin-4-ylidene)methyl)benzamido)-benzoic acid derivatives (8a-g) as potential type of FabH inhibitors is described. Their structures were confirmed by MS, NOE and 1H NMR.
English
Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors
Abstract:
A short and efficient synthesis of (Z)-2-substituted-5-(4-((2-substitued-5-oxoimidazolidin-4-ylidene)methyl)benzamido)-benzoic acid derivatives (8a-g) as potential type of FabH inhibitors is described. Their structures were confirmed by MS, NOE and 1H NMR.
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Key words:
- Tuberculosis
- / Mycobacterium tuberculosis FabH
- / Enzyme inhibitor
- / Synthesis
- / NOE
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