引用本文:
Jin Hui Yang, Wen Qian Huang, Jun Shan Luo, Dong Dong Guo, Yu Heng Zhang, Hong Jun Li. First total synthesis of (±)-sepicanin A[J]. Chinese Chemical Letters,
2012, 23(2): 127-129.
doi:
10.1016/j.cclet.2011.11.015
Citation: Jin Hui Yang, Wen Qian Huang, Jun Shan Luo, Dong Dong Guo, Yu Heng Zhang, Hong Jun Li. First total synthesis of (±)-sepicanin A[J]. Chinese Chemical Letters, 2012, 23(2): 127-129. doi: 10.1016/j.cclet.2011.11.015
Citation: Jin Hui Yang, Wen Qian Huang, Jun Shan Luo, Dong Dong Guo, Yu Heng Zhang, Hong Jun Li. First total synthesis of (±)-sepicanin A[J]. Chinese Chemical Letters, 2012, 23(2): 127-129. doi: 10.1016/j.cclet.2011.11.015
First total synthesis of (±)-sepicanin A
摘要:
A facile approach for the first total synthesis of naturally occurring geranylated flavanoids sepicanin A has been obtained with total yield 16% starting from 2, 4, 6-trihydroxyacetophenone after four steps. The key step was the protic acids (HCl or p-TsOH)-catalyzed benzopyrone formation in a protic polar solvent by deprotection and cyclization of chalcone in one step.
English
First total synthesis of (±)-sepicanin A
Abstract:
A facile approach for the first total synthesis of naturally occurring geranylated flavanoids sepicanin A has been obtained with total yield 16% starting from 2, 4, 6-trihydroxyacetophenone after four steps. The key step was the protic acids (HCl or p-TsOH)-catalyzed benzopyrone formation in a protic polar solvent by deprotection and cyclization of chalcone in one step.
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Key words:
- Sepicanin A
- / Flavanone
- / Geranylated flavonoids
- / Total synthesis
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