Citation: Jin Hui Yang, Wen Qian Huang, Jun Shan Luo, Dong Dong Guo, Yu Heng Zhang, Hong Jun Li. First total synthesis of (±)-sepicanin A[J]. Chinese Chemical Letters, ;2012, 23(2): 127-129. doi: 10.1016/j.cclet.2011.11.015 shu

First total synthesis of (±)-sepicanin A

State Key Laboratory Cultivation Base of Natural Gas Conversion, Ningxia University, Yinchuan 750021, China

Received Date: 6 September 2011

Fund Project: This work was financially supported by the National Natural Science Foundation (No. 20962016) and Ningxia Natural Science Foundation (No. NZ1006) and Program for New Century Excellent Talents in University (No. NCET-09-0860).

A facile approach for the first total synthesis of naturally occurring geranylated flavanoids sepicanin A has been obtained with total yield 16% starting from 2, 4, 6-trihydroxyacetophenone after four steps. The key step was the protic acids (HCl or p-TsOH)-catalyzed benzopyrone formation in a protic polar solvent by deprotection and cyclization of chalcone in one step.
- Sepicanin A,
- Flavanone,
- Geranylated flavonoids,
- Total synthesis
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