引用本文:
Wen Peng Mai, Jin Wei Yuan, Zhi Cheng Li, Gang Chun Sun. A copper-and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand[J]. Chinese Chemical Letters,
2012, 23(2): 185-188.
doi:
10.1016/j.cclet.2011.11.007
Citation: Wen Peng Mai, Jin Wei Yuan, Zhi Cheng Li, Gang Chun Sun. A copper-and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand[J]. Chinese Chemical Letters, 2012, 23(2): 185-188. doi: 10.1016/j.cclet.2011.11.007
Citation: Wen Peng Mai, Jin Wei Yuan, Zhi Cheng Li, Gang Chun Sun. A copper-and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand[J]. Chinese Chemical Letters, 2012, 23(2): 185-188. doi: 10.1016/j.cclet.2011.11.007
A copper-and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand
摘要:
An efficient palladium-catalyzed copper-and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new ligand. The use of 2 mol% Pd(OAc)2 in the presence of K2CO3 allows the coupling reaction to proceed at mild condition with good to excellent yields.
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关键词:
- Copper-free
- / Coupling
- / Sonogashira reaction
- / Chlorophosphine
English
A copper-and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand
Abstract:
An efficient palladium-catalyzed copper-and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new ligand. The use of 2 mol% Pd(OAc)2 in the presence of K2CO3 allows the coupling reaction to proceed at mild condition with good to excellent yields.
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Key words:
- Copper-free
- / Coupling
- / Sonogashira reaction
- / Chlorophosphine
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