Citation: Yan Chen, Rong Ning Liang, Wei Qin. Potentiometric sensor for sensitive and selective detection of heparin[J]. Chinese Chemical Letters, ;2012, 23(2): 233-236. doi: 10.1016/j.cclet.2011.10.021 shu

Potentiometric sensor for sensitive and selective detection of heparin

Yan Chen ^a,b, ,
Rong Ning Liang ^a ,
Wei Qin ^a

a CAS and Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China;
b Graduate University of the Chinese Academy of Sciences, Beijing 100049, China

Received Date: 25 August 2011

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 41176081), the Outstanding Youth Natural Science Foundation of Shandong Province (No. JQ200814), and the Taishan Scholar Program of Shandong Province (No. TS20081159).

A polymeric membrane ion-selective electrode for determination of heparin is described in this paper. Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin. The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate. The potentiometric response to the concentration of heparin is linear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL is achieved.
- Potentiometry,
- Sensing element,
- Heparin,
- Protamine,
- Polyion sensor
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