Citation: Jing Duan, Zhi Yong Guo. Development of a test strip based on DNA-functionalized gold nanoparticles for rapid detection of mercury(Ⅱ) ions[J]. Chinese Chemical Letters, ;2012, 23(2): 225-228. doi: 10.1016/j.cclet.2011.09.025 shu

Development of a test strip based on DNA-functionalized gold nanoparticles for rapid detection of mercury(Ⅱ) ions

Jing Duan ,
Zhi Yong Guo

Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China

Received Date: 14 July 2011

Fund Project: Financial supports from Science and Technology Department of Zhejiang Province of China (No. 2010C33004), Department of Education of Zhejiang Province (No. Y201010064) are gratefully acknowledged. This work was also sponsored by K.C. Wong Magna Fund in Ningbo University.

A rapid, sensitive, selective and reliable strip assay based on DNA-functionalized gold nanoparticles for Hg²⁺ detection has been developed, with a detection limit 5 nmol/L. The measurement principle was based on thymine-Hg²⁺-thymine (T-Hg²⁺-T) coordination chemistry and streptavidin-biotin interaction. The major advantages of this assay are that results can be read visually without any instrument in less than 10 min and that it does not require any sample pretreatment.
- Mercury (Ⅱ) ion,
- Test strip,
- Gold nanoparticles,
- DNA
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