Citation: Nilesh P. Tale, Girdharilal B. Tiwari, Nandkishor N. Karade. Un-catalyzed tandem Knoevenagel-Michael reaction for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) in aqueous medium[J]. Chinese Chemical Letters, ;2011, 22(12): 1415-1418. doi: 10.1016/j.cclet.2011.09.004 shu

Un-catalyzed tandem Knoevenagel-Michael reaction for the synthesis of 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) in aqueous medium

Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra 440 033, India

Received Date: 3 May 2011

Fund Project: The authors are thankful to the University Grants Commission, New Delhi, India (No.MRP 32-245/2006 SR) for the financial support.

An environmentally benign un-catalyzed one-pot synthesis of 4, 4'-(arylmethylene)bis (1H-pyrazol-5-ols) has been reported via tandem Knoevenagel-Michael reaction of aldehydes with two equivalents of 3-methyl-1-phenyl-1H-pyrazol-5 (4H)-one in aqueous medium.
- Knoevenagel reaction,
- Michael addition,
- Aldehydes,
- 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one,
- Aqueous medium
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