Citation: Jing Yang, Juan Zhang, Tian Tian Chen, De Mei Sun, Ji Li, Xue Fen Wu. Sulfamic acid as a cost-effective and recyclable solid acid catalyst for Friedel-Crafts alkylation of indole with α,β-unsaturated carbonyl compound and benzyl alcohol[J]. Chinese Chemical Letters, ;2011, 22(12): 1391-1394. doi: 10.1016/j.cclet.2011.06.006 shu

Sulfamic acid as a cost-effective and recyclable solid acid catalyst for Friedel-Crafts alkylation of indole with α,β-unsaturated carbonyl compound and benzyl alcohol

Jing Yang ^a, ,
Juan Zhang ^a ,
Tian Tian Chen ^b ,
De Mei Sun ^a ,
Ji Li ^c ,
Xue Fen Wu ^a

a Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China;
b Henan Chemical Industry Research Institute Co., Ltd., Zhengzhou 450052, China;
c Institute of Chemistry, Henan Academy of Science, Zhengzhou 450002, China

Received Date: 25 April 2011

Fund Project: We gratefully acknowledge the financial support from the Doctoral Research Fund of Henan University of Traditional Chinese Medicine.

Sulfamic acid was proved to be a cost-effective and recyclable catalyst for Friedel-Crafts type reaction of indole with α, β-unsaturated carbonyl compound and benzyl alcohol. Various indoles, α, β-unsaturated carbonyl compounds and a benzyl alcohol were successfully used in this type of reaction, and the corresponding products were obtained in good to excellent yields.
- Sulfamic acid,
- Michael reaction of indole,
- Acid catalysis,
- Alkylation of indole with benzyl alcohol
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