Citation: Xin Jian Song, Yu Shao, Xing Gao Dong. Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents[J]. Chinese Chemical Letters, ;2011, 22(9): 1036-1038. doi: 10.1016/j.cclet.2011.05.012 shu

Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents

a Key Laboratory of Biological Resources Protection and Utilization of Hubei Province, Hubei University for Nationalities, Enshi 445000, China;
b Medical School, Hubei University for Nationalities, Enshi 445000, China

Received Date: 30 December 2010

Fund Project: We are thankful for the National Nature Science Foundation of Hubei Province (No.2008CDB016) and the Scientific Research Fund of Hubei Provincial Education Department (No.D20111904).

A facile microwave-assisted procedure for synthesis of novel fluorinated pyrazolo[3, 4-d]pyrimidine derivatives containing 1, 3, 4-thiadiazole is described. This protocol presented such advantages as short reaction time, high yields, simple purification and environmentally benign procedures. Their antitumor activities were evaluated against HL-60 by an MTT assay. The preliminary results indicated that some title compounds exhibit more potent antitumor inhibitory activity than doxorubicin (DOX).
- Pyrazolo[3,4-d]pyrimidine,
- 1,3,4-Thiadiazole,
- Microwave-assisted synthesis,
- Antitumor activity
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