Citation: Tarek A. Salama, Saad S. Elmorsy. Silicon mediated synthesis and selected transformations of β-chloroketones[J]. Chinese Chemical Letters, ;2011, 22(10): 1171-1174. doi: 10.1016/j.cclet.2011.05.007 shu

Silicon mediated synthesis and selected transformations of β-chloroketones

Tarek A. Salama ^a,b, ,
Saad S. Elmorsy ^a

a Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt;
b Chemistry Department, Faculty of Education, Amran University, Amran, Yemen

Received Date: 16 February 2011

Fund Project: We are indebted to Prof.Mohamed.A.Ismail for generous spectroscopic assistance.

A combination of tetrachlorosilane (TCS) and phenol in dichloromethane was found to be an efficient reagent for hydro-chlorination of α, β-unsaturated ketones to afford the corresponding β-chloroketones in good yield at ambient temperature. Reactions of the titled compounds with TCS-NaN₃ as well as with nitriles utilizing TCS-ZnCl₂ to give 1, 5-disubstituted tetrazole derivatives or β-amido ketones respectively are also described.
- Tetrachlorosilane,
- Phenol,
- β-Chloroketones,
- Synthesis,
- Tetrazoles,
- β-Amido ketones
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