引用本文:
Jian Gao, Yang Hui Guo, Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. A novel and efficient route for the preparation of atorvastatin[J]. Chinese Chemical Letters,
2011, 22(10): 1159-1162.
doi:
10.1016/j.cclet.2011.04.016
Citation: Jian Gao, Yang Hui Guo, Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. A novel and efficient route for the preparation of atorvastatin[J]. Chinese Chemical Letters, 2011, 22(10): 1159-1162. doi: 10.1016/j.cclet.2011.04.016
Citation: Jian Gao, Yang Hui Guo, Ya Ping Wang, Xiang Jing Wang, Wen Sheng Xiang. A novel and efficient route for the preparation of atorvastatin[J]. Chinese Chemical Letters, 2011, 22(10): 1159-1162. doi: 10.1016/j.cclet.2011.04.016
A novel and efficient route for the preparation of atorvastatin
摘要:
A novel and efficient synthetic method of atorvastatin was described. The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction, resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C. This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.
English
A novel and efficient route for the preparation of atorvastatin
Abstract:
A novel and efficient synthetic method of atorvastatin was described. The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction, resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C. This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.
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Key words:
- Atorvastatin
- / Horner-Wadsworth-Emmons reaction
- / Synthesis
- / Intermediate
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