引用本文:
Xu Qin Li, Yun Xu Yang Wei Li Wang, Bin Hu, Hui Min Xue, Tian Yi Zhang, Xue Tao Zhang. Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol[J]. Chinese Chemical Letters,
2011, 22(7): 765-767.
doi:
10.1016/j.cclet.2011.01.007
Citation: Xu Qin Li, Yun Xu Yang Wei Li Wang, Bin Hu, Hui Min Xue, Tian Yi Zhang, Xue Tao Zhang. Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol[J]. Chinese Chemical Letters, 2011, 22(7): 765-767. doi: 10.1016/j.cclet.2011.01.007
Citation: Xu Qin Li, Yun Xu Yang Wei Li Wang, Bin Hu, Hui Min Xue, Tian Yi Zhang, Xue Tao Zhang. Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol[J]. Chinese Chemical Letters, 2011, 22(7): 765-767. doi: 10.1016/j.cclet.2011.01.007
Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol
摘要:
A practical chemical synthesis of L-carnitine (1) has been accomplished from (R)-3-chloro-l,2-propanediol ((R)-4), which is a main by-product originated from (R,R)-Salen Co(Ⅲ) catalyzed hydrolytic kinetic resolution (HKR) of (±)-epichlorohydrin (R)-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite ((R)-5). The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.
English
Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol
Abstract:
A practical chemical synthesis of L-carnitine (1) has been accomplished from (R)-3-chloro-l,2-propanediol ((R)-4), which is a main by-product originated from (R,R)-Salen Co(Ⅲ) catalyzed hydrolytic kinetic resolution (HKR) of (±)-epichlorohydrin (R)-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite ((R)-5). The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.
-
Key words:
- L-Camitine
- / Cyclic sulfite
- / (R)-3-Chloro-l,2-propanediol
扫一扫看文章
计量
- PDF下载量: 7
- 文章访问数: 1620
- HTML全文浏览量: 46
下载:
