Citation: Xu Qin Li, Yun Xu Yang Wei Li Wang, Bin Hu, Hui Min Xue, Tian Yi Zhang, Xue Tao Zhang. Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol[J]. Chinese Chemical Letters, ;2011, 22(7): 765-767. doi: 10.1016/j.cclet.2011.01.007 shu

Asymmetric synthesis of L-carnitine from (R)-3-chloro-1,2-propanediol

Department of Chemistry, University of Science and Technology Beijing, Beijing 100083, China

Received Date: 26 October 2010

Fund Project: the Natural Science Foundation of Beijing (No.2082016) and the Science and Technology Innovation Foundation for the College Students of Beijing (No.B091000814).The Project Sponsored by the National Natural Science Foundation of China (No.20972015)

A practical chemical synthesis of L-carnitine (1) has been accomplished from (R)-3-chloro-l,2-propanediol ((R)-4), which is a main by-product originated from (R,R)-Salen Co(Ⅲ) catalyzed hydrolytic kinetic resolution (HKR) of (±)-epichlorohydrin (R)-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite ((R)-5). The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.
- L-Camitine,
- Cyclic sulfite,
- (R)-3-Chloro-l,2-propanediol
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