引用本文:
Ning Zhang, Yi Su, Miao Yu. A novel cell-impermeable fluorescent zinc sensor containing poly(ethylene glycol) chain[J]. Chinese Chemical Letters,
2011, 22(7): 863-866.
doi:
10.1016/j.cclet.2011.01.006
Citation: Ning Zhang, Yi Su, Miao Yu. A novel cell-impermeable fluorescent zinc sensor containing poly(ethylene glycol) chain[J]. Chinese Chemical Letters, 2011, 22(7): 863-866. doi: 10.1016/j.cclet.2011.01.006
Citation: Ning Zhang, Yi Su, Miao Yu. A novel cell-impermeable fluorescent zinc sensor containing poly(ethylene glycol) chain[J]. Chinese Chemical Letters, 2011, 22(7): 863-866. doi: 10.1016/j.cclet.2011.01.006
A novel cell-impermeable fluorescent zinc sensor containing poly(ethylene glycol) chain
摘要:
A novel cell-impermeable zinc sensor was synthesized by incorporating poly(ethylene glycol) (PEG) to N-(8-quinolyl)-p-aminobenzenesulfonamide (HQAS) group. The polymeric zinc sensor combines both valuable features of HQAS and PEG. The HQAS of the sensor has the similar functions to TSQ, and exhibits a good fluorescence response to Zn2+ but poor fluorescence responses to other metal ions. The PEG chain can prevent the sensor to permeate healthy cell membrane. The stained experiments with the yeast cells as model showed that the sensor cannot stain the healthy yeast cells, but only the damaged or died yeast cells. These results indicated the novel zinc probe was a typical cell-impermeable zinc sensor.
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关键词:
- Zinc ion
- / Sensor
- / Yeast
- / Poly(ethylene glycol)
- / Fluorescence
English
A novel cell-impermeable fluorescent zinc sensor containing poly(ethylene glycol) chain
Abstract:
A novel cell-impermeable zinc sensor was synthesized by incorporating poly(ethylene glycol) (PEG) to N-(8-quinolyl)-p-aminobenzenesulfonamide (HQAS) group. The polymeric zinc sensor combines both valuable features of HQAS and PEG. The HQAS of the sensor has the similar functions to TSQ, and exhibits a good fluorescence response to Zn2+ but poor fluorescence responses to other metal ions. The PEG chain can prevent the sensor to permeate healthy cell membrane. The stained experiments with the yeast cells as model showed that the sensor cannot stain the healthy yeast cells, but only the damaged or died yeast cells. These results indicated the novel zinc probe was a typical cell-impermeable zinc sensor.
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Key words:
- Zinc ion
- / Sensor
- / Yeast
- / Poly(ethylene glycol)
- / Fluorescence
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