Citation: Chun Mei Zhang, Jun Xiang Guo, Liang Wang, Xiao Yun Chai, Hong Gang Hu, Qiu Ye Wu. Total synthesis of cyclic heptapeptide euryjanicin B[J]. Chinese Chemical Letters, ;2011, 22(6): 631-634. doi: 10.1016/j.cclet.2010.12.039 shu

Total synthesis of cyclic heptapeptide euryjanicin B

a Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
b School of Pharmacy, Yantai University, Yantai 264005, China

Received Date: 8 October 2010

Fund Project: This work was supported by grant from National Natural Science Foundation (No.20902109) and Science & Technology Commission of Shanghai Municipality (No.08JC1405500)

The first synthesis of the naturally occurring cyclic peptide euryjanicin B has been achieved.A general method was described to synthesize the cyclic peptide by a two-step solid-phase/solution synthesis strategy.All the amino acids in this study are L-configuration, The linear heptapeptide was assembled by standard Fmoc chemistry on solid-phase and subsequently cyclization was carried out by solution method.
- Cyclic peptide,
- Solid-phase synthesis,
- Cyclization,
- Purification,
- Euryjanicin B
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