引用本文:
Li Hong Shen, Ya Li, Da Hai Zhang, Yi Sheng Lai, Li Jie Liu. Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agent[J]. Chinese Chemical Letters,
2011, 22(7): 768-770.
doi:
10.1016/j.cclet.2010.12.037
Citation: Li Hong Shen, Ya Li, Da Hai Zhang, Yi Sheng Lai, Li Jie Liu. Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agent[J]. Chinese Chemical Letters, 2011, 22(7): 768-770. doi: 10.1016/j.cclet.2010.12.037
Citation: Li Hong Shen, Ya Li, Da Hai Zhang, Yi Sheng Lai, Li Jie Liu. Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agent[J]. Chinese Chemical Letters, 2011, 22(7): 768-770. doi: 10.1016/j.cclet.2010.12.037
Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agent
摘要:
To search for more potent antitumor agent, a series of novel nitric oxide-donating colchicine (Col) derivatives (6a-f, 8a and b) were synthesized by coupling nitrates with N-methyl colchiceinamide. Their cytotoxicity against four human cancer cell lines in vitro were evaluated by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compounds 6c, 8a and 8b showed more potent cytotoxic activities than Col.
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关键词:
- Colchicine
- / N-methyl colchiceinamide
- / Nitrates
- / Cytotoxicity
English
Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agent
Abstract:
To search for more potent antitumor agent, a series of novel nitric oxide-donating colchicine (Col) derivatives (6a-f, 8a and b) were synthesized by coupling nitrates with N-methyl colchiceinamide. Their cytotoxicity against four human cancer cell lines in vitro were evaluated by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compounds 6c, 8a and 8b showed more potent cytotoxic activities than Col.
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Key words:
- Colchicine
- / N-methyl colchiceinamide
- / Nitrates
- / Cytotoxicity
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