Citation: Jie Sun, c, Wei Xian Ding, Ke Yun Zhang, Yong Zou. Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives[J]. Chinese Chemical Letters, ;2011, 22(6): 677-670. doi: 10.1016/j.cclet.2010.12.017 shu

Efficient synthesis and biological evaluation of 4-arylcoumarin derivatives

Jie Sun ^a,,b, ,
c ^b ,
Wei Xian Ding ^a ,
Ke Yun Zhang ,
Yong Zou

a Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650, China;
b Department of Zoology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China;
c Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

Received Date: 29 September 2010

Two bioactive natural 4-arylcoumarins, 5,7,4'-trimethoxy-4-phenylcoumarin(1a), 5,7-dimethoxy-4-phenylcoumarin(1b)and five closely related derivatives 1c-g were synthesized.In vitro evaluation with a catechol subunit for antioxidant and antimicrobial activity, these compounds using standard methods showed that compounds 1d, 1f displayed promise radical scavenging activity and 1f was found to be the most active one against Bacillus dysenteriae.
- 4-Arylcoumarin,
- Synthesis,
- Antimicrobial,
- Antioxidant
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