Citation: Seyed Meysam Baghbanian, Maryam Farhang, Robabeh Baharfar. One-pot three-component synthesis of a-amino nitriles catalyzed by nano powder TiO₂ P25[J]. Chinese Chemical Letters, ;2011, 22(5): 555-558. doi: 10.1016/j.cclet.2010.12.003 shu

One-pot three-component synthesis of a-amino nitriles catalyzed by nano powder TiO₂ P25

a Chemistry Department, Islamic Azad University, Rasht Branch, Pole-taleshan, PO Box 41325-3516, Rasht, Iran;
b Department of Chemistry, Mazandaran University, Babolsar 47415, Iran

Received Date: 2 September 2010

A simple and efficient method has been developed for the synthesis of α-amino nitriles from aldehydes, amines and trimethylsilyl cyanide (Me₃ SiCN) in the presence of a catalytic amount of cyanuric acid at room temperature.
- Nano powder TiO₂ P25,
- α-Amino nitriles,
- One-pot three-component synthesis,
- Strecker reaction,
- Trimethylsilyl cyanide
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