Citation: Min Hui Cao, Sheng Zhen Xu, Chang Shui Chen. An efficient route for synthesis of 2-alkylamino benzo [b] thieno [3,2-d]pyrimidin-4(3H)-one[J]. Chinese Chemical Letters, ;2011, 22(4): 443-446. doi: 10.1016/j.cclet.2010.11.015 shu

An efficient route for synthesis of 2-alkylamino benzo [b] thieno [3,2-d]pyrimidin-4(3H)-one

College of Basic Science, Huazhong Agricultural University, Wuhan 430070, China

Received Date: 25 August 2010

Fund Project: We gratefully acknowledge financial supported by Huazhong Agricultural University Scientific & Technological Self-innovation Foundation (Nos. 2007XRC064 and 2008XKJC005).

The carbodiimide 2, obtained from the aza-Wittig reactions of iminophosphorane 1 with alkyl isocyanates, reacted with primary amino to give 2-alkylamino benzo[b]thieno[3,2-d]pyrimidin-4(3H)-ones 4 and 5. The formation mechanism of the title compounds has been investigated.
- Carbodiimides,
- Aza-Wittig reaction,
- Iminophosphorane,
- Isocyanates,
- Synthesis
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