Design, synthesis and biological evaluation of 1,4-dihydrothieno[3',2':5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists

• Rui Sun ^a, ,
• Jing Song ^a, ,
• Si Jie Liu ^a, ,
• Hui Zhao ^a, ,
• Chun Li Yan ^a, ,
• Ai Jun Zhang ^a, ,
• Diwa Koirala ^b, ,
• Da Wei Li ^b, ,
• Chun Hu ^a,

• a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, China; Department of Organic Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;

• b School of Pharmacy, Shanghai Jiao Tong University, Shanghai 300193, China

• Received Date: 18 June 2010
  
• Fund Project:

  This work was partially supported by the National Natural Science Foundation of China (NSFC) (No. 20474053).