Citation: Shan Bao Yu, Li Juan Zhang, Yu Luo, Wei Lu. A practical synthesis of 2-amino-5-methoxylpropiophenone[J]. Chinese Chemical Letters, ;2011, 22(1): 1-4. doi: 10.1016/j.cclet.2010.07.033 shu

A practical synthesis of 2-amino-5-methoxylpropiophenone

Shan Bao Yu ^a, ,
Li Juan Zhang ^a ,
Yu Luo ^a ,
Wei Lu ^b

a Department of Chemistry, East China Normal University, Shanghai 200062, China;
b Institute of Drug Discovery and Development, East China Normal University, Shanghai 200062, China

Received Date: 2 June 2010

Fund Project: We gratefully acknowledge the financial support from National Natural Science Foundation of China (No.305722321) and Shanghai Municipal Natural Science Foundation (No.10ZR1409600).We also thank Lab of Organic Functional Molecules,the Sino-French Institute of ECNU for supports.

This paper described a practical five-step synthetic approach for 2-amino-5-methoxylpropiophenone in 45% overall yield, using 3-chloropropiophenone as the starting material. The advantages of this procedure include short reaction steps, simple operation and good yield.
- Camptothecin,
- SN38,
- Synthesis
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