Citation: Parvin Kumar, Sunil Kumar, Khalid Husain, Ashwani Kumar. An efficient synthesis of pyrazole chalcones under solvent free conditions at room temperature[J]. Chinese Chemical Letters, ;2011, 22(1): 37-40. doi: 10.1016/j.cclet.2010.07.019 shu

An efficient synthesis of pyrazole chalcones under solvent free conditions at room temperature

a Chemistry Department, Guru Nanak Khalsa College, Haryana 135001, India;
b Chemistry Department, Government College, Haryana 125001, India;
c Drug Discovery and Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Haryana 125001, India

Received Date: 6 May 2010

Fund Project: The authors thank UGC for financial assistance to Dr. Sunil Kumar.

An easy, safe, solvent free and effective method for the synthesis of pyrazole-substituted chalcones has been achieved by grinding pyrazole aldehydes and acetophenones in the presence of activated barium hydroxide(C-200) in high yield within short span of time.All reactions were carried out just by grinding the two reactants in the presence of activated barium hydroxide(C-200).Results are also compared with sodium hydroxide and potassium hydroxide.
- Pyrazole aldehydes,
- Chalcones,
- Activated barium hydroxide(C-200),
- Solvent free conditions
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