Synthesis analogues of milbemycin and their bioactivity evaluation

Jin Hao Zhao Ming Hua Ji Xu Hui Xu Jing Li Cheng Guo Nian Zhu

引用本文: Jin Hao Zhao,  Ming Hua Ji,  Xu Hui Xu,  Jing Li Cheng,  Guo Nian Zhu. Synthesis analogues of milbemycin and their bioactivity evaluation[J]. Chinese Chemical Letters, 2010, 21(12): 1391-1394. doi: 10.1016/j.cclet.2010.06.035 shu
Citation:  Jin Hao Zhao,  Ming Hua Ji,  Xu Hui Xu,  Jing Li Cheng,  Guo Nian Zhu. Synthesis analogues of milbemycin and their bioactivity evaluation[J]. Chinese Chemical Letters, 2010, 21(12): 1391-1394. doi: 10.1016/j.cclet.2010.06.035 shu

Synthesis analogues of milbemycin and their bioactivity evaluation

  • 基金项目:

    This work is financially supported by National Natural Science Foundation of China (No.30700532) and the Science and Technology Project of Zhejiang province (No.2008C02007-3).

摘要: Eight new 13-O-aminocarbonylivermectin aglycones and 4'-O-aminocarbonylivermectin monosaccharide were synthesized from ivermectin aglycone and ivermectin monosaccharide by the selective protection of C5-OH group. Their bioactivities were evaluated against spicier mites (Tetranychus cinnabarinus), aphid (Aphis fabae) and orlental armyworm (Mythimma sepatara). Their structures were confirmed by 1H NMR. MS.

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  • 收稿日期:  2010-04-12
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