Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes

Yu Ming Cui Lai Lai Wang Fuk Yee Kwong Wei Sun

引用本文: Yu Ming Cui,  Lai Lai Wang,  Fuk Yee Kwong,  Wei Sun. Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes[J]. Chinese Chemical Letters, 2010, 21(12): 1403-1406. doi: 10.1016/j.cclet.2010.05.027 shu
Citation:  Yu Ming Cui,  Lai Lai Wang,  Fuk Yee Kwong,  Wei Sun. Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes[J]. Chinese Chemical Letters, 2010, 21(12): 1403-1406. doi: 10.1016/j.cclet.2010.05.027 shu

Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru (Ⅱ) complexes

  • 基金项目:

    We thank the National Natural Science Foundation of China (Nos.20343005,20473107,20673130,and 20773147) and the Hong Kong PolyU Joint Supervision Scheme (A-PH78) for financial support.

摘要: A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new ((Rax)-BuP)/(R, R)-DPEN-Ru (Ⅱ) complex catalyst system. The hydrogenation of 2-methylacetophenone in n-butanol (t-BuOK/Ru=45.6/1, S/C=500, 20 atm. Of H2, 20℃, 48h) afforded (S)-1-(2'-methylphenyl) ethanol in 92% ee and>99% conversion.

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  • 收稿日期:  2010-03-30
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