First total synthesis of ocimarin

引用本文: Jin Hui Yang, Yun Feng Li, Cong Bin Ji, Shi Zhi Jiang, Wan Yi Liu. First total synthesis of ocimarin[J]. Chinese Chemical Letters, 2010, 21(10): 1165-1166. doi: 10.1016/j.cclet.2010.04.038 shu

Citation: Jin Hui Yang, Yun Feng Li, Cong Bin Ji, Shi Zhi Jiang, Wan Yi Liu. First total synthesis of ocimarin[J]. Chinese Chemical Letters, 2010, 21(10): 1165-1166. doi: 10.1016/j.cclet.2010.04.038 shu

First total synthesis of ocimarin

a Key Laboratory of Energy Sources & Engineering, Ningxia University, Yinchuan 750021, China;
b School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China
基金项目:
This research work was financially supported by the National Natural Science Foundation of China (Nos.20562010,20962016),Ministry of National Education (No.203143) and Program for New Century Excellent Talents in University.

摘要: A facile approach for the first synthesis of ocimarin, naturally occurring coumarins, was developed by employing a cerium (Ⅲ) chloride heptahydrate-catalyzed Pechmann condensation of phenols and β-keto esters in a solvent-free system as key step, by which ocimarin was achieved by three steps starting from acetylacetic ether and resorcinol with total yield 23.2%. All structures of new compounds were confirmed by IR, ¹H NMR and MS.

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English

First total synthesis of ocimarin

a Key Laboratory of Energy Sources & Engineering, Ningxia University, Yinchuan 750021, China;
b School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China
Received Date: 23 February 2010
Fund Project:
This research work was financially supported by the National Natural Science Foundation of China (Nos.20562010,20962016),Ministry of National Education (No.203143) and Program for New Century Excellent Talents in University.

Abstract: A facile approach for the first synthesis of ocimarin, naturally occurring coumarins, was developed by employing a cerium (Ⅲ) chloride heptahydrate-catalyzed Pechmann condensation of phenols and β-keto esters in a solvent-free system as key step, by which ocimarin was achieved by three steps starting from acetylacetic ether and resorcinol with total yield 23.2%. All structures of new compounds were confirmed by IR, ¹H NMR and MS.

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First total synthesis of ocimarin

English

First total synthesis of ocimarin

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First total synthesis of ocimarin

English

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