引用本文:
Qiu Jin Zhang, Wei Pu Zhu, Zhi Quan Shen. Synthesis and characterization of biodegradable amphiphilic PEG-grafted poly (DTC-co-CL)[J]. Chinese Chemical Letters,
2010, 21(10): 1255-1258.
doi:
10.1016/j.cclet.2010.04.032
Citation: Qiu Jin Zhang, Wei Pu Zhu, Zhi Quan Shen. Synthesis and characterization of biodegradable amphiphilic PEG-grafted poly (DTC-co-CL)[J]. Chinese Chemical Letters, 2010, 21(10): 1255-1258. doi: 10.1016/j.cclet.2010.04.032
Citation: Qiu Jin Zhang, Wei Pu Zhu, Zhi Quan Shen. Synthesis and characterization of biodegradable amphiphilic PEG-grafted poly (DTC-co-CL)[J]. Chinese Chemical Letters, 2010, 21(10): 1255-1258. doi: 10.1016/j.cclet.2010.04.032
Synthesis and characterization of biodegradable amphiphilic PEG-grafted poly (DTC-co-CL)
摘要:
A novel biodegradable copolymer, poly (5, 5-dibromomethyltrimethylene carbonate-co-ε-caprolactone)(poly(DBTC-co-CL)) with pendant bromine groups, was synthesized via ring-opening polymerization(ROP)of ε-caprolactone(CL)and 5, 5-dibromomethyltrimethylene carbonate (DBTC) using stannous octoate (Sn(Oct)2) as catalyst. Then the pendant bromine groups were completely converted into azide form, which permitted "click" reaction with alkyne-terminated polyethylene (A-PEG) by Huisgen 1, 3-dipolar cycloadditions preparing biodegradable amphiphilic poly (DTC-co-CL)-g-PEG graft copolymer. The graft copolymer was characterized by nuclear magnetic resonance(NMR)and size-exclusion chromatography (SEC).
English
Synthesis and characterization of biodegradable amphiphilic PEG-grafted poly (DTC-co-CL)
Abstract:
A novel biodegradable copolymer, poly (5, 5-dibromomethyltrimethylene carbonate-co-ε-caprolactone)(poly(DBTC-co-CL)) with pendant bromine groups, was synthesized via ring-opening polymerization(ROP)of ε-caprolactone(CL)and 5, 5-dibromomethyltrimethylene carbonate (DBTC) using stannous octoate (Sn(Oct)2) as catalyst. Then the pendant bromine groups were completely converted into azide form, which permitted "click" reaction with alkyne-terminated polyethylene (A-PEG) by Huisgen 1, 3-dipolar cycloadditions preparing biodegradable amphiphilic poly (DTC-co-CL)-g-PEG graft copolymer. The graft copolymer was characterized by nuclear magnetic resonance(NMR)and size-exclusion chromatography (SEC).
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Key words:
- Polycarbonate
- / "Click" reaction
- / Graft copolymer
- / Ring-opening polymerization
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