引用本文:
Wen Li Xi, Qian Cai, Yan Bo Tang, Hua Sun, Zhi Yan Xiao. Design and synthesis of novel cytotoxic podophyllotoxin derivatives[J]. Chinese Chemical Letters,
2010, 21(10): 1153-1156.
doi:
10.1016/j.cclet.2010.03.040
Citation: Wen Li Xi, Qian Cai, Yan Bo Tang, Hua Sun, Zhi Yan Xiao. Design and synthesis of novel cytotoxic podophyllotoxin derivatives[J]. Chinese Chemical Letters, 2010, 21(10): 1153-1156. doi: 10.1016/j.cclet.2010.03.040
Citation: Wen Li Xi, Qian Cai, Yan Bo Tang, Hua Sun, Zhi Yan Xiao. Design and synthesis of novel cytotoxic podophyllotoxin derivatives[J]. Chinese Chemical Letters, 2010, 21(10): 1153-1156. doi: 10.1016/j.cclet.2010.03.040
Design and synthesis of novel cytotoxic podophyllotoxin derivatives
摘要:
In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N-and 4-C-substituted 4'-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10-7 mol/L level.
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关键词:
- Podophyllotoxin
- / C4-derivation
- / Cytotoxicity
English
Design and synthesis of novel cytotoxic podophyllotoxin derivatives
Abstract:
In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives, novel 4-N-and 4-C-substituted 4'-O-demethylepipodophyllotoxin derivatives were designed and synthesized. All the compounds were tested against A549 and MCF-7 tumor cells in vitro, and six compounds showed significant cytotoxicity. The most active compound 9f was superior to GL-331, and exhibited potent cytotoxicity with IC50 value at 10-7 mol/L level.
-
Key words:
- Podophyllotoxin
- / C4-derivation
- / Cytotoxicity
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