Citation: Han Bing Teng. The design and synthesis of a novel organophosphorus compound containing the structure of both β-amino acid and β-aminophosphonate[J]. Chinese Chemical Letters, ;2010, 21(7): 810-812. doi: 10.1016/j.cclet.2010.03.035 shu

The design and synthesis of a novel organophosphorus compound containing the structure of both β-amino acid and β-aminophosphonate

Han Bing Teng

College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China

Received Date: 24 November 2009

A novel organophosphorus compound containing the structure of both β-amino acid and B-aminophosphonate is designed and synthesized. Arbuzov reaction with P(OEt)₃, the N-Boc protected iodide 3 cannot provide the desired product but 2-oxazolidinone 4 because of the neighboring-group participation of the Boc moiety.To avoid the intramolecular participation of the carbamates, the Ts protecting group is employed and the Ts-protected iodide 5 affords the target product successfully.
- β-Amino acid,
- β-Aminophosphonate,
- Neighboring-group participation,
- Arbuzov reaction,
- Amino-protecting group
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